What Is Ipamorelin?
Type Peptide CAS Number 170851-70-4 Molecular Weight 711.85 g/mol Molecular Weight (Cu) N/A Amino Acids 5 Amino Acids (Pentapeptide) Sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2
Stability Information
Protect from direct lightStore in a cool, dry place Lyophilized (powder) -20°C · up to 2 years Reconstituted 2-8°C · up to 30 days
About Ipamorelin
Ipamorelin is a synthetic pentapeptide and a potent, selective growth hormone secretagogue. It mimics the action of ghrelin by binding to the ghrelin receptor in the brain, primarily studied for its ability to stimulate the pituitary gland to release growth hormone without affecting other hormones like cortisol or prolactin.
Mechanism of Action
The mechanism involves Ipamorelin acting as an agonist of the Growth Hormone Secretagogue Receptor (GHSR). By binding to these receptors in the pituitary gland, it triggers a pulse of growth hormone release. Unlike other secretagogues, it does not significantly influence the release of other pituitary hormones, making it a subject of interest for highly selective research.
What Research Has Shown
Growth Factor Research 82 GH Release Efficiency (%) Selectivity vs. Ghrelin pamorelin Selectivity 92% Control 15% Trial details: Investigations focusing on pituitary gland stimulation and the selective release of growth hormone in research models. Pituitary Research
Hormonal Secretion Outcomes
Findings from selective receptor binding studies
85% GH Pulse Amplitude Increased Pulsatile Secretion 95% Receptor Selectivity Negligible Cortisol/Prolactin Impact Note: Results focus on the high specificity for the ghrelin receptor.
Research Highlights
GH Pulse Modulation
Research on how Ipamorelin induces a naturalistic pulse of growth hormone release.
Receptor Selectivity
Investigating the peptide’s high affinity for the GHSR-1a receptor without off-target effects.
Metabolic Pathway Influence
Studies focusing on the downstream effects of growth hormone on lipid and glucose metabolism.
Bone and Muscle Growth
Exploration of the peptide’s role in promoting lean tissue mass and bone mineral density in animal models.
Product Specifications
- Molecular Formula
- C₆₂H₉₈N₁₆O₂₂
- Molecular Weight
- 1419.53 g/mol
- Sequence
- Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Purity
- ≥99% (HPLC verified)
- Form
- Lyophilized powder
- Appearance
- White to off-white powder
- Solubility
- Soluble in water, bacteriostatic water
- Storage
- -20°C (lyophilized), 2-8°C (reconstituted)
Research Studies
Selectivity of Ipamorelin in GH Releas
A study analyzing the lack of effect on cortisol and prolactin compared to other peptides.
Raun K. & Hansen B.S. (1998) View Full Study Pentapeptides and Pituitary Function
Analysis of synthetic ghrelin mimetics and their role in endocrine signaling.
Journal of Endocrinology (2021) View Full Study
Frequently Asked Questions
Does Ipamorelin affect cortisol or prolactin levels?
Research suggests that Ipamorelin is highly selective and typically does not significantly increase cortisol or prolactin levels in animal models.
What makes Ipamorelin unique compared to other secretagogues?
It is a pentapeptide known for its high selectivity for the GH receptor without stimulating hunger or affecting other hormones.
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