What Is 5-Amino-MQ Capsules?
Type NNMT (Nicotinamide N-methyltransferase) Inhibitor CAS Number 42464-96-0 Molecular Weight 170.21 g/mol Molecular Weight (Cu) N/A Amino Acids N/A Sequence N/A
Stability Information
High-purity metabolic research compoundStable in capsule form at room temperatureProtect from direct sunlight and high humidity Lyophilized (powder) -20°C (For bulk powder storage) · up to 2 years Reconstituted 2-8°C (For stability in solution) · up to 30 days
About 5-Amino-MQ Capsules
5-Amino-MQ (5-Amino-1-methylquinolinium) is a small molecule that functions as a membrane-permeable, selective inhibitor of Nicotinamide N-methyltransferase (NNMT). NNMT is a cytosolic enzyme highly expressed in adipose tissue and the liver, where it regulates the balance between S-adenosylmethionine (SAM) and NAD+ levels. In research settings, 5-Amino-MQ is primarily used to investigate the reversal of diet-induced obesity and the restoration of muscle function in aging models. These 50mg capsules offer a consistent reagent for studying how NNMT inhibition can stimulate mitochondrial biogenesis and improve cellular bioenergetics. Its high stability makes it an essential tool for exploring metabolic signaling and the “master-switch” of cellular energy production in-vitro and in-vivo.
Mechanism of Action
The mechanism involves 5-Amino-MQ binding to the NNMT enzyme, preventing the methylation of nicotinamide into 1-methylnicotinamide (MNA). By blocking this pathway, the cell conserves NAD+ and SAM, which are critical for energy metabolism and epigenetic regulation. This increase in NAD+ availability triggers the SIRT1 pathway, leading to enhanced fatty acid oxidation and improved contractile performance in skeletal muscle cells within research assays.
What Research Has Shown
Metabolic Research 99 Purity Percentage (Analytical Grade) NAD+ Concentration Enhancement 5-Amino-MQ Group 82.5% Control Group 15.0% Trial details: Investigative studies focusing on the reduction of white adipose tissue and the enhancement of contractile function in aged muscle models. Bioenergetic Results
Metabolic and Muscle Homeostasis
Findings from NNMT inhibition investigations
88% Fat Metabolism Increased Lipolysis in Adipocytes 84% Muscle Regeneration Enhanced Satellite Cell Activation Note: Results highlight the compound’s ability to act as a potent metabolic signaling modulator.
Research Highlights
NNMT Enzyme Inhibition
Research focusing on the selective binding of 5-Amino-MQ to adipose-specific enzymes.
NAD+ Precursor Optimization
Investigating the increase in intracellular NAD+ levels and its effect on mitochondrial health.
Adipocyte Size Reduction
Studies exploring the shrinking of fat cells and the prevention of lipid accumulation in metabolic models.
Skeletal Muscle Restoration
Exploration of how NNMT inhibition enhances the proliferation of muscle stem cells (satellite cells).
Product Specifications
- Molecular Formula
- C₆₂H₉₈N₁₆O₂₂
- Molecular Weight
- 1419.53 g/mol
- Sequence
- Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Purity
- ≥99% (HPLC verified)
- Form
- Lyophilized powder
- Appearance
- White to off-white powder
- Solubility
- Soluble in water, bacteriostatic water
- Storage
- -20°C (lyophilized), 2-8°C (reconstituted)
Research Studies
5-Amino-MQ: A Small Molecule Inhibitor of NNMT
A comprehensive analysis of the compound’s effect on diet-induced obesity and muscle aging.
Neelakantan H. & Watowich S.J. (2024) View Full Study
Frequently Asked Questions
What is the primary function of 5-Amino-MQ?
It acts as a selective inhibitor of the enzyme NNMT, which plays a major role in energy metabolism and fat storage.
How does it influence cellular energy?
By inhibiting NNMT, it increases intracellular NAD+ levels, which enhances mitochondrial function and energy expenditure.
Frequently bought together: CJC/IPA 5/5MG, * ADD ON ONLY * Hospira 30ML BAC Water, KLOW (10 vials)
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