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Type Coenzyme / Redox Cofactor CAS Number 53-84-9 Molecular Weight 663.43 g/mol Molecular Weight (Cu) N/A Amino Acids N/A (Nucleotide structure) Sequence N/A
High-purity lyophilized coenzyme (Oxidized Form)Essential for redox reactions and mitochondrial activityHighly sensitive to light and moisture Lyophilized (powder) –20 °C · up to 2 years Reconstituted 2-8 °C · up to 30 days
NAD⁺ (Nicotinamide Adenine Dinucleotide, Oxidized Form) is a crucial coenzyme found in all living cells, playing a central role in redox reactions, energy metabolism, and cellular signaling. In research, NAD⁺ is widely used as a biochemical reagent to investigate oxidative pathways, enzyme catalysis, and cellular aging mechanisms. Its essential function in metabolic regulation and mitochondrial activity makes NAD⁺ a cornerstone compound in molecular biology, enzymology, and longevity studies. This high-purity lyophilized form is optimized for consistent results in in vitro and in vivo experimental models, providing a reliable standard for investigating the biochemical foundations of life.
The mechanism involves NAD⁺ acting as a primary electron carrier in redox reactions. During cellular respiration, NAD⁺ accepts electrons from metabolic substrates, becoming reduced to NADH. This NADH then provides the electrons needed for the electron transport chain in the mitochondria to produce ATP. Furthermore, NAD⁺ acts as a signaling molecule and cofactor for Sirtuins (longevity-linked enzymes) and PARPs (DNA repair enzymes). By donating its ADP-ribose moiety, NAD⁺ enables these enzymes to regulate gene expression, maintain genomic stability, and optimize cellular stress responses in research assays.
Metabolic Research 98 Purity Percentage (HPLC Verified) Mitochondrial Efficiency & Redox Cycling NAD⁺ Supplemented 92.5% NAD⁺ Depleted Control 36.0% Trial details: Investigative studies focusing on the activation of sirtuin pathways, enzyme cofactor activity, and mitochondrial bioenergetics in experimental longevity models. Bioenergetic Results
Findings from oxidative pathway and redox studies
95% Mitochondrial Function Enhanced ATP Production 88% Sirtuin Activation Increased Deacetylation Activity Note: Results highlight NAD⁺ as a cornerstone compound for investigating cellular aging and energy metabolism.
Redox Cycling Investigation
Research focusing on the NAD⁺/NADH ratio and its impact on cellular oxidative stress.
Mitochondrial Bioenergetics
Investigating the coenzyme’s role in ATP synthesis and energy metabolism regulation.
Investigating the coenzyme’s role in ATP synthesis and energy metabolism regulation.
Sirtuin Pathway Activation
DNA Repair Mechanisms
Exploration of NAD⁺ as a substrate for PARP-mediated detection and repair of genomic damage.
NAD⁺: The Essential Catalyst of Mitochondrial Function
A comprehensive analysis of nicotinamide adenine dinucleotide in redox biology and energy metabolism.
Imai S. & Guarente L. View Full Study
What is the fundamental difference between NAD⁺ and NADH?
NAD⁺ is the oxidized form of the coenzyme, which acts as an electron acceptor, whereas NADH is the reduced form that acts as an electron donor.
Why is NAD⁺ critical for DNA repair?
It serves as an essential substrate for PARP enzymes, which identify and initiate the repair process for damaged DNA strands.
