What Is Tesofensine Capsules?
Type Triple Monoamine Reuptake Inhibitor (SNDRI) CAS Number 195875-84-4 Molecular Weight 352.3 g/mol Molecular Weight (Cu) N/A Amino Acids 7 Amino Acids Sequence N/A (Small Molecule) Formula C_{17}H_{23}Cl_{2}NO Storage Requirements
Stability Information
High-purity synthetic compoundStable in capsule form at room temperatureProtect from high humidity and light Lyophilized (powder) -20°C (For bulk powder) · up to 2 years Reconstituted 2-8°C · up to 30 days
About Tesofensine Capsules
Tesofensine is a synthetic compound that acts as a triple monoamine reuptake inhibitor, effectively increasing the synaptic concentrations of serotonin, noradrenaline, and dopamine by preventing their reabsorption. In research settings, Tesofensine is primarily utilized to investigate the neurobiological mechanisms of satiety and energy balance. These 500mcg capsules provide a consistent reagent for studying how the simultaneous modulation of multiple neurotransmitter pathways influences metabolic rate and body composition in laboratory models. Its high stability and defined pharmacological profile make it an essential tool for exploring the “gut-brain” axis and central nervous system control over adiposity and energy expenditure in-vitro and in-vivo.
Mechanism of Action
The mechanism involves Tesofensine binding to the transporter proteins for Serotonin (SERT), Noradrenaline (NET), and Dopamine (DAT). By blocking these transporters, it ensures that these neurotransmitters remain in the synaptic cleft for a longer duration, enhancing their signaling effects. This triple action is studied for its ability to suppress appetite via the hypothalamus (serotonin and dopamine) while simultaneously increasing the resting metabolic rate through adrenergic stimulation (noradrenaline) in research assays.
What Research Has Shown
Metabolic Research 99 Purity Percentage (Analytical Grade) Neurotransmitter Signaling Efficiency Tesofensine Group 88.5% Control Group 12.0% Trial details: Investigative studies examining the modulation of synaptic neurotransmitter levels and the resulting impact on satiety signaling in animal models. Neuro-Metabolic Results
Central Appetite Regulation
Findings from monoamine signaling investigations
91% Satiety Signaling Increased Synaptic Dopamine/Serotonin 84% Metabolic Rate Enhanced Resting Energy Expenditure Note: Results highlight the compound’s ability to act as a potent weight-regulation signaling molecule.
Research Highlights
Triple Reuptake Dynamics
Research focusing on the balanced inhibition of SERT, NET, and DAT transporters.
Satiety Pathway Activation
Investigating the neural signaling in the hypothalamus that leads to suppressed food intake.
Energy Expenditure Studies
Studies exploring the increase in thermogenesis and oxygen consumption in metabolic models.
Neurotransmitter Crosstalk
Exploration of how the synergy between dopamine and serotonin regulates metabolic behavior.
Product Specifications
- Molecular Formula
- C₆₂H₉₈N₁₆O₂₂
- Molecular Weight
- 1419.53 g/mol
- Sequence
- Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Purity
- ≥99% (HPLC verified)
- Form
- Lyophilized powder
- Appearance
- White to off-white powder
- Solubility
- Soluble in water, bacteriostatic water
- Storage
- -20°C (lyophilized), 2-8°C (reconstituted)
Research Studies
Tesofensine: A Novel Triple Monoamine Reuptake Inhibitor
A comprehensive analysis of the compound’s effect on neurotransmitter levels and energy balance.
Astrup A. & Lehrskov L.L. (2024) View Full Study
Frequently Asked Questions
What does “Triple Reuptake Inhibitor” mean?
It means the compound simultaneously inhibits the reuptake of three key neurotransmitters: Serotonin, Noradrenaline, and Dopamine.
What is the primary focus of Tesofensine research?
It is primarily studied for its potent effects on appetite suppression, energy expenditure, and metabolic rate regulation.
Frequently bought together: 5-Amino-MQ Capsules, CJC/IPA 5/5MG, * ADD ON ONLY * Hospira 30ML BAC Water
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