What Is Glutathione?
Type Natural Tripeptide CAS Number 70-18-8 Molecular Weight 307.32 g/mol Molecular Weight (Cu) N/A Amino Acids Glutamic Acid, Cysteine, Glycine Sequence γ-L-Glutamyl-L-cysteinyl-glycine Formula C_{10}H_{17}N_{3}O_{6}S Storage Requirements
Stability Information
High-purity lyophilized stable reagentContains active thiol (–SH) groupProtect from light and moisture Lyophilized (powder) -20°C · up to 2 years Reconstituted 2-8°C · up to 30 days
About Glutathione
Glutathione (GSH) is a naturally occurring tripeptide and a powerhouse antioxidant found within cells. It is essential for researchers studying how cells defend themselves against oxidative damage and how metabolic pathways manage detoxification and chemical stressors.
Mechanism of Action
The mechanism involves Glutathione acting as a potent electron donor. Through its active thiol group, it directly neutralizes reactive oxygen species (ROS) and free radicals. It also functions as a necessary cofactor for enzymes like Glutathione S-transferase, facilitating the conjugation and removal of toxins from the cellular environment.
What Research Has Shown
Redox Biology Research 98 Purity Percentage (HPLC) Oxidative Stress Mitigation GSH Treated Group 89.5% Control Group 18.2% Trial details: Investigative research focusing on free-radical scavenging, cellular defense systems, and mitochondrial protection mechanisms. Detoxification Results
Cellular Redox Homeostasis
Findings from metabolic signaling investigations
92% ROS Neutralization Reduced Oxidative DNA Damage 85% Detoxification Enhanced Conjugation of Toxins Note: Results highlight the peptide’s efficiency as a cofactor for detoxification enzymes.
Research Highlights
Redox Balance Maintenance
Research on how GSH sustains the equilibrium between oxidants and antioxidants in the cell.
Mitochondrial Protection
Investigating the role of glutathione in safeguarding mitochondrial DNA from oxidative decay.
Enzyme Cofactor Activity
Studies exploring the interaction between GSH and antioxidant enzymes like Glutathione Peroxidase.
Detoxification Signaling
Exploration of the pathways through which GSH aids in the neutralization of metabolic byproducts.
Product Specifications
- Molecular Formula
- C₆₂H₉₈N₁₆O₂₂
- Molecular Weight
- 1419.53 g/mol
- Sequence
- Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Purity
- ≥99% (HPLC verified)
- Form
- Lyophilized powder
- Appearance
- White to off-white powder
- Solubility
- Soluble in water, bacteriostatic water
- Storage
- -20°C (lyophilized), 2-8°C (reconstituted)
Research Studies
Glutathione and Cellular Defense Systems
A comprehensive review of tripeptide-mediated protection against free radicals and oxidative stress.
Meister A. & Anderson M.E. View Full Study Advances in Redox Biology
Analysis of glutathione’s role as a master regulator in biochemical and pharmacological assays.
Journal of Biological Chemistry (2022) View Full Study
Frequently Asked Questions
Why is the thiol (–SH) group important in Glutathione?
The unique thiol group enables direct participation in redox reactions and serves as a critical cofactor for antioxidant enzymes.
What is the primary role of GSH in cellular biology?
It plays a central role in maintaining cellular redox balance, detoxification pathways, and protection against oxidative stress.
Frequently bought together: Epithalon, Tesa/Ipa Blend (10MG/3MG), KPV Capsules
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