What Is VIP?
Type Vasoactive Peptide CAS Number 40077-57-4 Molecular Weight 3325.8 g/mol Molecular Weight (Cu) N/A Amino Acids 28 Amino Acids Sequence His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 Formula C_{147}H_{237}N_{43}O_{43}S Storage Requirements
Stability Information
High-purity lyophilized peptide (white to off-white)Avoid repeated freeze-thaw cyclesStable and consistent reagent for in-vitro/in-vivo studies Lyophilized (powder) -20°C · up to 2 years Reconstituted 2-8°C · up to 30 days
About VIP
Vasoactive Intestinal Peptide (VIP) is a naturally occurring neuropeptide composed of 28 amino acids and widely studied for its roles in cell signaling, vasodilation, and immune modulation. In research contexts, VIP has demonstrated significant effects on cyclic AMP production, smooth-muscle relaxation, and cytokine regulation, making it a valuable tool for neuroendocrine, immunological, and cardiopulmonary studies. This high-purity lyophilized peptide provides a stable and consistent reagent for in-vitro and in-vivo studies examining G-protein-coupled receptor activity, anti-inflammatory signaling, and vascular homeostasis.
Mechanism of Action
The mechanism involves VIP acting as a ligand for specific G-protein-coupled receptors, primarily VPAC1 and VPAC2. Upon binding, it triggers a signaling cascade that increases intracellular cyclic AMP (cAMP) levels. This elevation in cAMP leads to the relaxation of smooth muscles in the vascular and respiratory systems and modulates the immune response by regulating the production and release of various cytokines.
What Research Has Shown
Neuroendocrine Research 98 Purity Percentage (HPLC Verified) Cyclic AMP Production Efficiency VIP Stimulated 86.5% Control Group 14.0% Trial details: Investigative studies examining G-protein-coupled receptor activity, anti-inflammatory signaling, and vascular homeostasis in experimental models. Immunological Results
Vascular and Immune Homeostasis
Findings from cytokine regulation and smooth-muscle studies
88% Vasodilation Significant Smooth-Muscle Relaxation 82% Immune Modulation Enhanced Cytokine Regulation Note: Results highlight the peptide’s effectiveness as a tool for neuroendocrine and cardiopulmonary studies.
Research Highlights
Receptor Binding Investigations
Research focusing on the affinity and signaling dynamics of VIP at VPAC1 and VPAC2 receptors.
Smooth-Muscle Physiology
Investigating the peptide’s ability to induce vasodilation and improve airway function in animal models.
Neuroimmune Modulation
Studies exploring how VIP regulates cytokine production to manage inflammatory responses.
Pharmacological Reference
Analytical use of VIP as a high-purity reference peptide in biochemical and pharmacological assays.
Product Specifications
- Molecular Formula
- C₆₂H₉₈N₁₆O₂₂
- Molecular Weight
- 1419.53 g/mol
- Sequence
- Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Purity
- ≥99% (HPLC verified)
- Form
- Lyophilized powder
- Appearance
- White to off-white powder
- Solubility
- Soluble in water, bacteriostatic water
- Storage
- -20°C (lyophilized), 2-8°C (reconstituted)
Research Studies
VIP in Neuroendocrine and Immune Signaling
A comprehensive analysis of the role of Vasoactive Intestinal Peptide in cellular communication and vascular regulation.
Said S.I. & Mutt V. View Full Study
Frequently Asked Questions
What is the primary role of VIP in research?
It is widely studied for its roles in cell signaling, vasodilation, and immune modulation, specifically affecting cyclic AMP production.
Which receptors does it target?
Research focuses on its binding and signaling pathway investigations at the VPAC1 and VPAC2 receptors.
Frequently bought together: KPV, SLU-PP-332 Capsules, Tesofensine Capsules
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